It seems like my guy friend is very depressed, and think's everyone is out to get him? He also cut's himself, and think's no girl on earth would date him. How can I help comfort him?

Ngaww , this seems like a pretty hard situation you’re in ,
honestly you can help him , but personally you need to be trustworthy
understanding and there for him , this may be due to bad past experiences , heartbreak , bullying . Depression doesn’t occur overnight , he may be in pain or mentallydepressed , you need to talk to him , listen to him . Firstly when you listen to him , don’t judge or criticize him because eg. He says he doesn’t get any girls and it hurts him , don’t just be like , ‘ dude stop okay , its only chicks , they stupid’ , be sympathetic and understanding , listen to him , don’t butt ( is that the word? ) in when hes talking , comfort him be there for him , firstly make yourself someone that is not out to get him , be there for him , a friend , don’t leave him when hes in a bad situation he will feel even more helpless , though you may not have to be involved in all his problems , it is you volunteering to help him which is awesome , tell him about his talents and things thats you like about him and the great qualities about him , and don’t try to say the negative things about him eg. To tell him why no girls like him . Good luck but its good to be a good listener and don’t give up on him , because if you weren’t there he would be deeper in a hole than before